Conversations I Wish I Had

Genomic sequencing reveals mutations, insights into 2014 Ebola outbreak

After Big Bang

In response to an ongoing, unprecedented outbreak of Ebola virus disease in West Africa, a team of researchers has rapidly sequenced and analyzed more than 99 Ebola virus genomes. Their findings could have important implications for rapid field diagnostic tests.

Created by CDC microbiologist Frederick A. Murphy, this colorized transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by an Ebola virus virion. Credit: CDC/Frederick A. Murphy Created by CDC microbiologist Frederick A. Murphy, this colorized transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by an Ebola virus virion.
Credit: CDC/Frederick A. Murphy

For the current study, researchers sequenced 99 Ebola virus genomes collected from 78 patients diagnosed with Ebola in Sierra Leone during the first 24 days of the outbreak (a portion of the patients contributed samples more than once, allowing researchers a clearer view into how the virus can change in a single individual over the course of infection). The team found more than 300 genetic changes that make the 2014 Ebola virus genomes distinct from the viral genomes tied to previous…

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This entry was posted on August 30, 2015 by .
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